GenieFluor 488 Anti-Human CD40 Antibody [3A8]
- SKU:
- AGEL2797
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Applications:
- FCM
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- Mouse IgG2a, κ
- Clone:
- 3A8
- Conjugation:
- AF488
Description
| Product Name: | GenieFluor 488 Anti-Human CD40 Antibody [3A8] |
| Product Code: | AGEL2797 |
| Clone No: | 3A8 |
| Synonyms: | Tumor necrosis factor receptor superfamily member 5,Cd40,B-cell surface antigen CD40,Bp50,CD40L receptor,CD40,Tnfrsf5 |
| Reactivity: | Human |
| Host Species: | Mouse |
| Applications: | FCM |
| Isotype: | Mouse IgG2a, κ |
| Isotype Control: | GenieFluor 488 Mouse IgG2a, κ Isotype Control [C1.18.4] (AGEL2580) |
| Conjugation: | AF488 |
| Form: | Liquid |
| Fluorescent Label: | AF488 is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 520 nm (e.g., a 525/40 nm bandpass filter). |
| Recommended Use: | Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. |
| Storage Buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Swissprot: | P25942 |
| Stability & Storage: | Keep as concentrated solution. Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
| Shipping: | Biological ice pack at 4°C |
CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand). The 5C3 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA, partially blocking CD40 binding to CD40L, and B cells rescue from apoptosis.
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