Gdf5 Antibody (PACO26937)
- SKU:
- PACO26937
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Gdf5 Antibody (PACO26937) |
| Antibody SKU: | PACO26937 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:10-1:100 |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Growth/differentiation factor 5 protein (376-495AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded mouse liver tissue using PACO26937 at dilution of 1:50. |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO26937 at dilution of 1:20. |
| Background: | Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B |
| Synonyms: | Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14), Gdf5, Bmp14 Bp Gdf-5 |
| UniProt Protein Function: | GDF5: a cytokine that is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. These cytokines are characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Binds to bone morphogenetic protein receptors (BMPRs), a family of transmembrane serine/threonine kinases. BMPRs are involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B. Defects in GDF5 are the cause of acromesomelic chondrodysplasia Grebe type (AMDG), acromesomelic chondrodysplasia Hunter-Thompson type (AMDH), brachydactyly type C (BDC), Du Pan syndrome (DPS), symphalangism proximal syndrome (SYM1), multiple synostoses syndrome type 2 (SYNS2), and brachydactyly type A2 (BDA2). Genetic variations in GDF5 are associated with susceptibility to osteoarthritis type 5 (OS5). Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Cellular Component: extracellular space; membrane; extracellular region; plasma membrane Molecular Function:identical protein binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding; receptor binding Biological Process: hindlimb morphogenesis; regulation of multicellular organism growth; BMP signaling pathway; forelimb morphogenesis; positive regulation of chondrocyte differentiation; cartilage development; regulation of MAPKKK cascade; transmembrane receptor protein serine/threonine kinase signaling pathway; chondrocyte differentiation; negative regulation of neuron apoptosis; positive regulation of neuron differentiation; cell development; embryonic limb morphogenesis; negative regulation of epithelial cell proliferation; growth |
| UniProt Code: | P43027 |
| NCBI GenInfo Identifier: | 341940738 |
| NCBI Gene ID: | 14563 |
| NCBI Accession: | P43027.2 |
| UniProt Secondary Accession: | P43027,A2ARK2, |
| UniProt Related Accession: | P43027 |
| Molecular Weight: | 54,895 Da |
| NCBI Full Name: | Growth/differentiation factor 5 |
| NCBI Synonym Full Names: | growth differentiation factor 5 |
| NCBI Official Symbol: | Gdf5 |
| NCBI Official Synonym Symbols: | bp; brp; BMP-14; Cdmp-1 |
| NCBI Protein Information: | growth/differentiation factor 5; GDF-5; brachypodism; bone morphogenetic protein 14; cartilage-derived morphogenetic protein-1 |
| UniProt Protein Name: | Growth/differentiation factor 5 |
| UniProt Synonym Protein Names: | Bone morphogenetic protein 14; BMP-14 |
| UniProt Gene Name: | Gdf5 |
| UniProt Entry Name: | GDF5_MOUSE |
| ELISA Kits |
| Mouse GDF-5 / BMP14 ELISA Kit |
| Mouse GDF5 (Growth Differentiation Factor 5) CLIA Kit (MOES00317) |
| Mouse Growth/differentiation factor 5 (Gdf5) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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