Antibody Name:	GDF11 Antibody (PACO19357)
Antibody SKU:	PACO19357
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human GDF11

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human lymphoma tissue using PACO19357(GDF11 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19357(GDF11 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-β superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.

Synonyms:

growth differentiation factor 11

UniProt Protein Function:	GDF11: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Belongs to the TGF-beta family.
UniProt Protein Details:	Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 12q13.2 Cellular Component: extracellular space; intracellular membrane-bound organelle; nucleoplasm; protein complex Molecular Function:cytokine activity; growth factor activity; transforming growth factor beta receptor binding Biological Process: camera-type eye morphogenesis; cell development; cell maturation; growth; mesoderm development; metanephros development; negative regulation of cell proliferation; negative regulation of neuron differentiation; nervous system development; palate development; pancreas development; regulation of apoptosis; regulation of MAPKKK cascade; skeletal development; spinal cord anterior/posterior patterning; ureteric bud development
NCBI Summary:	The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]
UniProt Code:	O95390
NCBI GenInfo Identifier:	12643335
NCBI Gene ID:	10220
NCBI Accession:	O95390.1
UniProt Secondary Accession:	O95390,Q9UID1, Q9UID2,
UniProt Related Accession:	O95390
Molecular Weight:	45,091 Da
NCBI Full Name:	Growth/differentiation factor 11
NCBI Synonym Full Names:	growth differentiation factor 11
NCBI Official Symbol:	GDF11
NCBI Official Synonym Symbols:	BMP11; BMP-11
NCBI Protein Information:	growth/differentiation factor 11
UniProt Protein Name:	Growth/differentiation factor 11
UniProt Synonym Protein Names:	Bone morphogenetic protein 11; BMP-11
UniProt Gene Name:	GDF11
UniProt Entry Name:	GDF11_HUMAN