GCNT2 Antibody (PACO09436)
- SKU:
- PACO09436
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | GCNT2 Antibody (PACO09436) |
| Antibody SKU: | PACO09436 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human GCNT2 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group);GCNT2;CCAT;GCNT2C;GCNT5;IGNT;II;MGC163396;NACGT1;NAGCT1;ULG3;bA360O19.2;bA421M1.1 ; |
| UniProt Protein Function: | GCNT2A: Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C. Belongs to the glycosyltransferase 14 family. 3 isoforms of the human protein are produced by alternative splicingProtein type: EC 2.4.1.150Chromosomal Location of Human Ortholog: 6p24.2Cellular Component: Golgi membrane; membrane; integral to membraneMolecular Function: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activityBiological Process: glycosaminoglycan biosynthetic process; positive regulation of protein kinase B signaling cascade; positive regulation of heterotypic cell-cell adhesion; multicellular organismal development; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; protein amino acid glycosylation; positive regulation of cell migrationDisease: Blood Group, I System |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q06430 |
| NCBI GenInfo Identifier: | 21717810 |
| NCBI Gene ID: | 2651 |
| NCBI Accession: | NP_663624.1 |
| UniProt Secondary Accession: | Q06430 |
| UniProt Related Accession: | Q06430, Q8N0V5, Q8NFS9 |
| Molecular Weight: | 45,873 Da |
| NCBI Full Name: | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform A |
| NCBI Synonym Full Names: | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) |
| NCBI Official Symbol: | GCNT2 |
| NCBI Official Synonym Symbols: | II; CCAT; IGNT; ULG3; GCNT5; GCNT2C; NACGT1; NAGCT1; CTRCT13; bA421M1.1; bA360O19.2 |
| NCBI Protein Information: | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase |
| UniProt Protein Name: | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A |
| UniProt Synonym Protein Names: | I-branching enzyme; IGNT |
| Protein Family: | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase |
| UniProt Gene Name: | GCNT2 |
| UniProt Entry Name: | GNT2A_HUMAN |
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