| UniProt Protein Function: | GCHFR: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. Belongs to the GFRP family.Protein type: InhibitorChromosomal Location of Human Ortholog: 15q15Cellular Component: cytoplasm; cytosol; dendrite; melanosome; nuclear membrane; nucleusMolecular Function: protein bindingBiological Process: neurotransmitter metabolic process; nitric oxide biosynthetic process; regulation of nitric-oxide synthase activity |
| UniProt Protein Details: | |
| NCBI Summary: | GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P30047 |
| NCBI GenInfo Identifier: | 2506906 |
| NCBI Gene ID: | 2644 |
| NCBI Accession: | P30047.3 |
| UniProt Secondary Accession: | P30047,Q2M1Q2, Q99749, B2R4L6, B7ZLM8 |
| UniProt Related Accession: | P30047 |
| Molecular Weight: | 8,555 Da |
| NCBI Full Name: | GTP cyclohydrolase 1 feedback regulatory protein |
| NCBI Synonym Full Names: | GTP cyclohydrolase I feedback regulator |
| NCBI Official Symbol: | GCHFR |
| NCBI Official Synonym Symbols: | P35; GFRP; HsT16933 |
| NCBI Protein Information: | GTP cyclohydrolase 1 feedback regulatory protein |
| UniProt Protein Name: | GTP cyclohydrolase 1 feedback regulatory protein |
| UniProt Synonym Protein Names: | GTP cyclohydrolase I feedback regulatory protein; p35 |
| Protein Family: | GTP cyclohydrolase 1 feedback regulatory protein |
| UniProt Gene Name: | GCHFR |
| UniProt Entry Name: | GFRP_HUMAN |
