Name: GCHFR Antibody (PACO45858)
SKU: PACO45858
Availability: OutOfStock

Antibody Name:	GCHFR Antibody (PACO45858)
Antibody SKU:	PACO45858
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, IHC, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:	Human
Immunogen:	Recombinant Human GTP cyclohydrolase 1 feedback regulatory protein (11-55AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO45858 at dilution of 1:100.
	Immunofluorescent analysis of Hela cells using PACO45858 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Background:	Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
Synonyms:	GTP cyclohydrolase 1 feedback regulatory protein (GFRP) (GTP cyclohydrolase I feedback regulatory protein) (p35), GCHFR, GFRP

UniProt Protein Function:	GCHFR: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. Belongs to the GFRP family.Protein type: InhibitorChromosomal Location of Human Ortholog: 15q15Cellular Component: cytoplasm; cytosol; dendrite; melanosome; nuclear membrane; nucleusMolecular Function: protein bindingBiological Process: neurotransmitter metabolic process; nitric oxide biosynthetic process; regulation of nitric-oxide synthase activity
UniProt Protein Details:
NCBI Summary:	GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]
UniProt Code:	P30047
NCBI GenInfo Identifier:	2506906
NCBI Gene ID:	2644
NCBI Accession:	P30047.3
UniProt Secondary Accession:	P30047,Q2M1Q2, Q99749, B2R4L6, B7ZLM8
UniProt Related Accession:	P30047
Molecular Weight:	8,555 Da
NCBI Full Name:	GTP cyclohydrolase 1 feedback regulatory protein
NCBI Synonym Full Names:	GTP cyclohydrolase I feedback regulator
NCBI Official Symbol:	GCHFR
NCBI Official Synonym Symbols:	P35; GFRP; HsT16933
NCBI Protein Information:	GTP cyclohydrolase 1 feedback regulatory protein
UniProt Protein Name:	GTP cyclohydrolase 1 feedback regulatory protein
UniProt Synonym Protein Names:	GTP cyclohydrolase I feedback regulatory protein; p35
Protein Family:	GTP cyclohydrolase 1 feedback regulatory protein
UniProt Gene Name:	GCHFR
UniProt Entry Name:	GFRP_HUMAN