Name: GCHFR Antibody (PACO22357)
SKU: PACO22357
Availability: OutOfStock

Antibody Name:	GCHFR Antibody (PACO22357)
Antibody SKU:	PACO22357
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from internal of human GCHFR.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using GCHFR antibody.

Background:	Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
Synonyms:	GTP cyclohydrolase 1 feedback regulatory protein; GTP cyclohydrolase I feedback regulatory protein; GFRP; p35;

UniProt Protein Function:	GCHFR: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. Belongs to the GFRP family.Protein type: InhibitorChromosomal Location of Human Ortholog: 15q15Cellular Component: cytoplasm; cytosol; dendrite; melanosome; nuclear membrane; nucleusMolecular Function: protein bindingBiological Process: neurotransmitter metabolic process; nitric oxide biosynthetic process; regulation of nitric-oxide synthase activity
UniProt Protein Details:
NCBI Summary:	GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]
UniProt Code:	P30047
NCBI GenInfo Identifier:	2506906
NCBI Gene ID:	2644
NCBI Accession:	P30047.3
UniProt Secondary Accession:	P30047,Q2M1Q2, Q99749, B2R4L6, B7ZLM8
UniProt Related Accession:	P30047
Molecular Weight:	8,555 Da
NCBI Full Name:	GTP cyclohydrolase 1 feedback regulatory protein
NCBI Synonym Full Names:	GTP cyclohydrolase I feedback regulator
NCBI Official Symbol:	GCHFR
NCBI Official Synonym Symbols:	P35; GFRP; HsT16933
NCBI Protein Information:	GTP cyclohydrolase 1 feedback regulatory protein
UniProt Protein Name:	GTP cyclohydrolase 1 feedback regulatory protein
UniProt Synonym Protein Names:	GTP cyclohydrolase I feedback regulatory protein; p35
Protein Family:	GTP cyclohydrolase 1 feedback regulatory protein
UniProt Gene Name:	GCHFR
UniProt Entry Name:	GFRP_HUMAN