Description
Antibody Name: | GCHFR Antibody (PACO09431) |
Antibody SKU: | PACO09431 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human GCHFR |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | GTP cyclohydrolase I feedback regulator;GCHFR;GFRP;HsT16933;MGC138467;MGC138469;P35 ; |
UniProt Protein Function: | GCHFR: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. Belongs to the GFRP family.Protein type: InhibitorChromosomal Location of Human Ortholog: 15q15Cellular Component: cytoplasm; cytosol; dendrite; melanosome; nuclear membrane; nucleusMolecular Function: protein bindingBiological Process: neurotransmitter metabolic process; nitric oxide biosynthetic process; regulation of nitric-oxide synthase activity |
UniProt Protein Details: | |
NCBI Summary: | GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008] |
UniProt Code: | P30047 |
NCBI GenInfo Identifier: | 2506906 |
NCBI Gene ID: | 2644 |
NCBI Accession: | P30047.3 |
UniProt Secondary Accession: | P30047,Q2M1Q2, Q99749, B2R4L6, B7ZLM8 |
UniProt Related Accession: | P30047 |
Molecular Weight: | 8,555 Da |
NCBI Full Name: | GTP cyclohydrolase 1 feedback regulatory protein |
NCBI Synonym Full Names: | GTP cyclohydrolase I feedback regulator |
NCBI Official Symbol: | GCHFR |
NCBI Official Synonym Symbols: | P35; GFRP; HsT16933 |
NCBI Protein Information: | GTP cyclohydrolase 1 feedback regulatory protein |
UniProt Protein Name: | GTP cyclohydrolase 1 feedback regulatory protein |
UniProt Synonym Protein Names: | GTP cyclohydrolase I feedback regulatory protein; p35 |
Protein Family: | GTP cyclohydrolase 1 feedback regulatory protein |
UniProt Gene Name: | GCHFR |
UniProt Entry Name: | GFRP_HUMAN |