Name: GBP4 Antibody (PACO57396)
SKU: PACO57396
Availability: OutOfStock

Antibody Name:	GBP4 Antibody (PACO57396)
Antibody SKU:	PACO57396
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:200-1:500
Species Reactivity:	Human
Immunogen:	Recombinant Human Guanylate-binding protein 4 protein (494-603AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western Blot. Positive WB detected in: 293T whole cell lysate. All lanes: GBP4 antibody at 2.6µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 74 kDa. Observed band size: 74 kDa.
	IHC image of PACO57396 diluted at 1:800 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
	IHC image of PACO57396 diluted at 1:800 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Background:	Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).
Synonyms:	Guanylate-binding protein 4 (EC 3.6.5) (GTP-binding protein 4) (GBP-4) (Guanine nucleotide-binding protein 4), GBP4

UniProt Protein Function:	GBP4: Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation. Belongs to the GBP family.
UniProt Protein Details:	Protein type:Cell adhesion; Hydrolase; Vesicle Chromosomal Location of Human Ortholog: 1p22.2 Cellular Component: Golgi membrane; nucleus; perinuclear region of cytoplasm Molecular Function:GTP binding; GTPase activity Biological Process: metabolic process
NCBI Summary:	Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008]
UniProt Code:	Q96PP9
NCBI GenInfo Identifier:	116242487
NCBI Gene ID:	115361
NCBI Accession:	Q96PP9.2
UniProt Secondary Accession:	Q96PP9,Q05D63, Q6NSL0, Q86T99, B2R630,
UniProt Related Accession:	Q96PP9
Molecular Weight:	73,165 Da
NCBI Full Name:	Guanylate-binding protein 4
NCBI Synonym Full Names:	guanylate binding protein 4
NCBI Official Symbol:	GBP4
NCBI Official Synonym Symbols:	Mpa2
NCBI Protein Information:	guanylate-binding protein 4
UniProt Protein Name:	Guanylate-binding protein 4
UniProt Synonym Protein Names:	GTP-binding protein 4; GBP-4; Guanine nucleotide-binding protein 4
Protein Family:	Guanylate-binding protein
UniProt Gene Name:	GBP4
UniProt Entry Name:	GBP4_HUMAN

Antibodies	ELISA Kits
GBP4 Antibody (PACO02432)	Human Guanylate-binding protein 4 (GBP4) ELISA Kit
GBP4 Antibody (PACO09427)

Secondary Antibody

Neuroimmunologie: Das Immunsystem des ZNS

Interleukin-8-Signalisierung