GATAD2A Antibody (PACO57284)
- SKU:
- PACO57284
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | GATAD2A Antibody (PACO57284) |
| Antibody SKU: | PACO57284 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:500-1:1000 |
| Species Reactivity: | Human, Rat |
| Immunogen: | Recombinant Human Transcriptional repressor p66-α protein (170-241AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, 293 whole cell lysate, HL60 whole cell lysate, MCF-7 whole cell lysate, Rat stomach tissue. All lanes: GATAD2A antibody at 2.9µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 69, 66 kDa. Observed band size: 69 kDa. |
 | IHC image of PACO57284 diluted at 1:800 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO57284 diluted at 1:800 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B. |
| Synonyms: | Transcriptional repressor p66-α (Hp66alpha) (GATA zinc finger domain-containing protein 2A), GATAD2A |
| UniProt Protein Function: | GATAD2A: Transcriptional repressor. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 19p13.11Cellular Component: nucleoplasm; nuclear speck; NuRD complex; nucleusMolecular Function: protein binding, bridging; protein binding; zinc ion binding; sequence-specific DNA binding; transcription factor activityBiological Process: blood vessel development; embryonic body morphogenesis; neural fold formation; transcription, DNA-dependent; anterior neuropore closure; in utero embryonic development; DNA methylation; programmed cell death; negative regulation of transcription, DNA-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q86YP4 |
| NCBI GenInfo Identifier: | 164519146 |
| NCBI Gene ID: | 54815 |
| NCBI Accession: | NP_060130.3 |
| UniProt Secondary Accession: | Q86YP4 |
| UniProt Related Accession: | Q86YP4 |
| Molecular Weight: | |
| NCBI Full Name: | transcriptional repressor p66-alpha isoform 2 |
| NCBI Synonym Full Names: | GATA zinc finger domain containing 2A |
| NCBI Official Symbol: | GATAD2A |
| NCBI Official Synonym Symbols: | p66alpha |
| NCBI Protein Information: | transcriptional repressor p66-alpha |
| UniProt Protein Name: | Transcriptional repressor p66-alpha |
| UniProt Synonym Protein Names: | GATA zinc finger domain-containing protein 2A |
| Protein Family: | Transcriptional repressor |
| UniProt Gene Name: | GATAD2A |
| UniProt Entry Name: | P66A_HUMAN |
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