Product Name:	GATA6 Transcription Factor Activity Assay
Product Code:	TFAB00117
Target:	GATA6
Synonyms:	GATA-binding factor 6
Reactivity:	Human, Mouse, Rat
Sample Types:	Nuclear or cell lysates

The Assay Genie GATA6 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:	4.5 hours
Detection Method:	Colorimetric 450 nm
Size:	12 x 8-Well Microstrips
Storage:	4°C for 6 months

UniProt Protein Function:	GATA6: Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation.
UniProt Protein Details:	Protein type:Motility/polarity/chemotaxis; Transcription factor Chromosomal Location of Human Ortholog: 18q11.1-q11.2 Cellular Component: nucleoplasm; nucleus; transcription factor complex Molecular Function:chromatin binding; protein binding; protein kinase binding; transcription factor activity; transcription factor binding Biological Process: blood coagulation; cell development; cell fate commitment; cellular protein metabolic process; male gonad development; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor-beta1 production; negative regulation of transforming growth factor-beta2 production; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; response to drug; smooth muscle cell differentiation; transcription from RNA polymerase II promoter Disease: Atrial Septal Defect 9; Atrioventricular Septal Defect 5; Conotruncal Heart Malformations; Heart Defects, Congenital, And Other Congenital Anomalies; Tetralogy Of Fallot
NCBI Summary:	This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]
UniProt Code:	Q92908
NCBI GenInfo Identifier:	215273987
NCBI Gene ID:	2627
NCBI Accession:	Q92908.2
UniProt Secondary Accession:	Q92908,P78327, B0YJ17,
UniProt Related Accession:	Q92908
Molecular Weight:	45,386 Da
NCBI Full Name:	Transcription factor GATA-6
NCBI Synonym Full Names:	GATA binding protein 6
NCBI Official Symbol:	GATA6
NCBI Protein Information:	transcription factor GATA-6
UniProt Protein Name:	Transcription factor GATA-6
UniProt Synonym Protein Names:	GATA-binding factor 6
Protein Family:	GATA transcription factor
UniProt Gene Name:	GATA6
UniProt Entry Name:	GATA6_HUMAN