GAREM1 Antibody (PACO40586)
- SKU:
- PACO40586
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | GAREM1 Antibody (PACO40586) |
| Antibody SKU: | PACO40586 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human GRB2-associated and regulator of MAPK protein (12-320AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using PACO40586 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO40586 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. |
| Synonyms: | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1), GAREM1, C18orf11 FAM59A GAREM |
| UniProt Protein Function: | GAREM: a protein of unknown function. Contains a predicted ATPase (AAA+ superfamily).Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 18q12.1Cellular Component: plasma membraneMolecular Function: protein bindingBiological Process: epidermal growth factor receptor signaling pathway; positive regulation of cell division; positive regulation of cell proliferation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q9H706 |
| NCBI GenInfo Identifier: | 125991851 |
| NCBI Gene ID: | 64762 |
| NCBI Accession: | Q9H706.2 |
| UniProt Secondary Accession: | Q9H706,Q0VAG3, Q0VAG4, Q8ND03, Q9BSF5 |
| UniProt Related Accession: | Q9H706 |
| Molecular Weight: | 97,099 Da |
| NCBI Full Name: | GRB2-associated and regulator of MAPK protein |
| NCBI Synonym Full Names: | GRB2 associated, regulator of MAPK1 |
| NCBI Official Symbol: | GAREM |
| NCBI Official Synonym Symbols: | Gm944; FAM59A; C18orf11 |
| NCBI Protein Information: | GRB2-associated and regulator of MAPK protein; protein FAM59A; GRB2-associated and regulator of MAPK1; Grb2-associated and regulator of Erk/MAPK; family with sequence similarity 59, member A |
| UniProt Protein Name: | GRB2-associated and regulator of MAPK protein |
| UniProt Synonym Protein Names: | GRB2-associated and regulator of MAPK1 |
| Protein Family: | |
| UniProt Gene Name: | GAREM |
| UniProt Entry Name: | GAREM_HUMAN |
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