GALR1 Antibody (PACO55514)
- SKU:
- PACO55514
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | GALR1 Antibody (PACO55514) |
| Antibody SKU: | PACO55514 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Galanin receptor type 1 protein (293-349AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: HepG2 whole cell lysate. All lanes: GALR1 antibody at 2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 39 kDa. Observed band size: 39 kDa. |
| Background: | Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. |
| Synonyms: | Galanin receptor type 1 (GAL1-R) (GALR-1), GALR1, GALNR GALNR1 |
| UniProt Protein Function: | GALR1: Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 18q23 Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane Molecular Function:galanin receptor activity; peptide hormone binding; protein binding Biological Process: digestion; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of cortisol secretion; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P47211 |
| NCBI GenInfo Identifier: | 311033447 |
| NCBI Gene ID: | 2587 |
| NCBI Accession: | P47211.3 |
| UniProt Secondary Accession: | P47211,Q4VBL7, |
| UniProt Related Accession: | P47211 |
| Molecular Weight: | 38,953 Da |
| NCBI Full Name: | Galanin receptor type 1 |
| NCBI Synonym Full Names: | galanin receptor 1 |
| NCBI Official Symbol: | GALR1 |
| NCBI Official Synonym Symbols: | GALNR; GALNR1 |
| NCBI Protein Information: | galanin receptor type 1 |
| UniProt Protein Name: | Galanin receptor type 1 |
| Protein Family: | Galanin receptor |
| UniProt Gene Name: | GALR1 |
| UniProt Entry Name: | GALR1_HUMAN |
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