GALNT12 Antibody (PACO37782)
- SKU:
- PACO37782
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | GALNT12 Antibody (PACO37782) |
| Antibody SKU: | PACO37782 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 12 protein (1-272AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO37782 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO37782 at dilution of 1:100. |
| Background: | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs. |
| Synonyms: | Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12), GALNT12 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.[provided by RefSeq, Mar 2011] |
| UniProt Code: | Q8IXK2 |
| NCBI GenInfo Identifier: | 15530299 |
| NCBI Gene ID: | 79695 |
| NCBI Accession: | AAH13945.1 |
| UniProt Secondary Accession: | Q8IXK2,Q5TCF7, Q8NG54, Q96CT9, Q9H771 |
| UniProt Related Accession: | Q8IXK2 |
| Molecular Weight: | 31,726 Da |
| NCBI Full Name: | GALNT12 protein |
| NCBI Synonym Full Names: | polypeptide N-acetylgalactosaminyltransferase 12 |
| NCBI Official Symbol: | GALNT12 |
| NCBI Official Synonym Symbols: | CRCS1; GalNAc-T12 |
| NCBI Protein Information: | polypeptide N-acetylgalactosaminyltransferase 12; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12); colorectal cancer, susceptibility to 1; polype |
| UniProt Protein Name: | |
| UniProt Synonym Protein Names: | |
| Protein Family: | Polypeptide N-acetylgalactosaminyltransferase |
| UniProt Gene Name: | |
| UniProt Entry Name: |
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