Description
Antibody Name: | GALNT11 Antibody (PACO46946) |
Antibody SKU: | PACO46946 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 11 protein (420-606AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO46946 at dilution of 1:100. | |
Immunofluorescent analysis of Hela cells using PACO46946 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human cervical cancer using PACO46946 at dilution of 1:100. |
Background: | Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO). |
Synonyms: | Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11), GALNT11 |
UniProt Protein Function: | GALNT11: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward Muc1, Muc4.1, and EA2 than GALNT1. Does not appear to be involved in glycosylation of erythropoietin. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 2.4.1.41; Transferase; Membrane protein, integral; Glycan Metabolism - O-glycan biosynthesisChromosomal Location of Human Ortholog: 7q36.1|7q36.1Cellular Component: Golgi membraneMolecular Function: Notch binding; polypeptide N-acetylgalactosaminyltransferase activityBiological Process: determination of left/right symmetry; Notch receptor processing; O-glycan processing; protein amino acid O-linked glycosylation via threonine; regulation of Notch signaling pathway |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q8NCW6 |
NCBI GenInfo Identifier: | 51316030 |
NCBI Gene ID: | 63917 |
NCBI Accession: | Q8NCW6.2 |
UniProt Secondary Accession: | Q8NCW6,Q6PCD1, Q9H6C2, Q9H6Z5, Q9UDR8, B3KWF4 |
UniProt Related Accession: | Q8NCW6 |
Molecular Weight: | 23,090 Da |
NCBI Full Name: | Polypeptide N-acetylgalactosaminyltransferase 11 |
NCBI Synonym Full Names: | polypeptide N-acetylgalactosaminyltransferase 11 |
NCBI Official Symbol: | GALNT11 |
NCBI Official Synonym Symbols: | GALNACT11; GALNAC-T11 |
NCBI Protein Information: | polypeptide N-acetylgalactosaminyltransferase 11 |
UniProt Protein Name: | Polypeptide N-acetylgalactosaminyltransferase 11 |
UniProt Synonym Protein Names: | Polypeptide GalNAc transferase 11; GalNAc-T11; pp-GaNTase 11; Protein-UDP acetylgalactosaminyltransferase 11; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11 |
Protein Family: | Polypeptide N-acetylgalactosaminyltransferase |
UniProt Gene Name: | GALNT11 |
UniProt Entry Name: | GLT11_HUMAN |