| UniProt Protein Function: | GAK: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Protein type: Cell cycle regulation; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; EC 2.7.11.1; Kinase, protein; Other group; NAK familyChromosomal Location of Human Ortholog: 4p16Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; membrane; vesicleMolecular Function: protein bindingBiological Process: Golgi organization and biogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] |
| UniProt Code: | O14976 |
| NCBI GenInfo Identifier: | 17375734 |
| NCBI Gene ID: | 2580 |
| NCBI Accession: | O14976.2 |
| UniProt Secondary Accession: | O14976,Q5U4P5, Q9BVY6 |
| UniProt Related Accession: | O14976 |
| Molecular Weight: | 134,464 Da |
| NCBI Full Name: | Cyclin-G-associated kinase |
| NCBI Synonym Full Names: | cyclin G associated kinase |
| NCBI Official Symbol: | GAK |
| NCBI Official Synonym Symbols: | DNAJ26; DNAJC26 |
| NCBI Protein Information: | cyclin-G-associated kinase |
| UniProt Protein Name: | Cyclin-G-associated kinase |
| UniProt Synonym Protein Names: | |
| Protein Family: | Cyclin-G-associated kinase |
| UniProt Gene Name: | GAK |
| UniProt Entry Name: | GAK_HUMAN |
