| UniProt Protein Function: | GADD45GIP1: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. Interacts with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1 AB domain. Interacts with the human papilloma virus type 16 (HPV 16) minor capsid protein L2. Down-regulated by p53/TP53 in apoptotic cells. Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.Protein type: Nuclear receptor co-regulator; Cell cycle regulationChromosomal Location of Human Ortholog: 19p13.2Cellular Component: mitochondrion; mitochondrial matrix; nucleusMolecular Function: protein bindingBiological Process: viral reproduction; mitochondrial translation; organelle organization and biogenesis; cell cycle |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012] |
| UniProt Code: | Q8TAE8 |
| NCBI GenInfo Identifier: | 74730346 |
| NCBI Gene ID: | 90480 |
| NCBI Accession: | Q8TAE8.1 |
| UniProt Secondary Accession: | Q8TAE8,Q8IVM3, Q8TE51, Q969P9, Q9BSM6 |
| UniProt Related Accession: | Q8TAE8 |
| Molecular Weight: | 25kDa |
| NCBI Full Name: | Growth arrest and DNA damage-inducible proteins-interacting protein 1 |
| NCBI Synonym Full Names: | growth arrest and DNA-damage-inducible, gamma interacting protein 1 |
| NCBI Official Symbol: | GADD45GIP1 |
| NCBI Official Synonym Symbols: | PRG6; CRIF1; PLINP; CKBBP2; Plinp1; MRP-L59; PLINP-1; CKbetaBP2 |
| NCBI Protein Information: | growth arrest and DNA damage-inducible proteins-interacting protein 1; CR6 interacting factor 1; CKII beta binding protein 2; CKII beta-associating protein; p53-responsive gene 6 protein; 39S ribosomal protein L59, mitochondrial; papillomavirus L2 interacting nuclear protein 1; growth arrest- and DNA damage-inducible GADD45G-interacting protein |
| UniProt Protein Name: | Growth arrest and DNA damage-inducible proteins-interacting protein 1 |
| UniProt Synonym Protein Names: | 39S ribosomal protein L59, mitochondrial; MRP-L59; CKII beta-associating protein; CR6-interacting factor 1; CRIF1; Papillomavirus L2-interacting nuclear protein 1; PLINP; PLINP-1; p53-responsive gene 6 protein |
| Protein Family: | Growth arrest and DNA damage-inducible protein |
| UniProt Gene Name: | GADD45GIP1 |
| UniProt Entry Name: | G45IP_HUMAN |
