GAD65/GAD2 Monoclonal Antibody
- SKU:
- CAB22728
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | GAD65/GAD2 Monoclonal Antibody |
| Product Code: | CAB22728 |
| Reactivity: | Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC58332 |
| Reactivity: | Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:2000-1:10000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse brain, Mouse liver(Negative control), Rat brain |
| Cellular Location: | Cell junction, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Golgi apparatus membrane, Lipid-anchor, Peripheral membrane protein, cytosol, presynaptic cell membrane, synapse |
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-125of human GAD65/GAD2 (NP_000809.1). |
| Sequence: | MASPG SGFWS FGSED GSGDS ENPGT ARAWC QVAQK FTGGI GNKLC ALLYG DAEKP AESGG SQPPR AAARK AACAC DQKPC SCSKV DVNYA FLHAT DLLPA CDGER PTLAF LQDVM NILLQ YVVKS |
| Synonyms: | GAD65 |
| Calculated MW: | 65kDa |
| Observed MW: | 65kDa |
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