Antibody Name:	GAD2 Antibody (PACO23107)
Antibody SKU:	PACO23107
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100
Species Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from human GAD1/GAD2.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western blot analysis of extracts from mouse brain cells, using GAD1/2 antibody.
	Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using GAD1/2 antibody.

Background:

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

Synonyms:

Glutamate decarboxylase 2; EC 4.1.1.15; Glutamate decarboxylase 65 kDa isoform; GAD-65; 65 kDa glutamic acid decarboxylase

UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q4G154
NCBI GenInfo Identifier:	121943966
NCBI Gene ID:	0
NCBI Accession:	Q4G154
UniProt Secondary Accession:	Q4G154
UniProt Related Accession:	Q4G154
Molecular Weight:	21,147 Da
NCBI Full Name:	GAD2 protein
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:	GAD2 protein
UniProt Synonym Protein Names:	GAD2 protein
Protein Family:	Glutamate decarboxylase
UniProt Gene Name:	GAD2
UniProt Entry Name:	Q4G154_HUMAN