Antibody Name:	GAD1/GAD2 Antibody (PACO06500)
Antibody SKU:	PACO06500
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC, IF
Recommended Dilutions:	ELISA:1:5000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from the C-terminal region of human GAD-65/67.

Form:	Liquid
Storage Buffer:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western Blot analysis of various cells using GAD-65/67 Polyclonal Antibody.
	Western Blot analysis of mouse cells using GAD-65/67 Polyclonal Antibody.

Synonyms:

GAD1; GAD; GAD67; Glutamate decarboxylase 1; 67 kDa glutamic acid, decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform; GAD2; GAD65; Glutamate decarboxylase 2; 65 kDa glutamic acid, decarboxylase; GAD-65; Glutamate decarboxylase 65

UniProt Protein Function:	GAD67: Catalyzes the production of GABA. Homodimer. Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. Belongs to the group II decarboxylase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:EC 4.1.1.15; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - taurine and hypotaurine; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial; Lyase Chromosomal Location of Human Ortholog: 2q31 Cellular Component: plasma membrane; intracellular; vesicle membrane Molecular Function:protein binding; glutamate binding; glutamate decarboxylase activity; protein heterodimerization activity; protein N-terminus binding; pyridoxal phosphate binding Biological Process: response to drug; glutamate catabolic process; synaptic transmission; glutamate decarboxylation to succinate; neurotransmitter secretion; gamma-aminobutyric acid biosynthetic process; protein-pyridoxal-5-phosphate linkage; neurotransmitter biosynthetic process Disease: Cerebral Palsy, Spastic Quadriplegic, 1
NCBI Summary:	This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]
UniProt Code:	Q99259
NCBI GenInfo Identifier:	1352213
NCBI Gene ID:	2571
NCBI Accession:	Q99259.1
UniProt Secondary Accession:	Q99259,Q49AK1, Q53TQ7, Q9BU91, Q9UHH4,
UniProt Related Accession:	Q99259
Molecular Weight:	66,897 Da
NCBI Full Name:	Glutamate decarboxylase 1
NCBI Synonym Full Names:	glutamate decarboxylase 1 (brain, 67kDa)
NCBI Official Symbol:	GAD1
NCBI Official Synonym Symbols:	GAD; SCP; CPSQ1
NCBI Protein Information:	glutamate decarboxylase 1; GAD-67; 67 kDa glutamic acid decarboxylase; glutamate decarboxylase 67 kDa isoform
UniProt Protein Name:	Glutamate decarboxylase 1
UniProt Synonym Protein Names:	67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform
Protein Family:	Glutamate decarboxylase
UniProt Gene Name:	GAD1
UniProt Entry Name:	DCE1_HUMAN