G6PC Rabbit pAb
- SKU:
- CAB21168
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Applications:
- WB
- Isotype:
- IgG
- Host Species:
- Rabbit
Description
| Product Name: | G6PC Rabbit pAb |
| Product Code: | CAB21168 |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human G6PC (NP_000142.2). |
| Applications: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse small intestine, Rat liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human G6PC (NP_000142.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SIYN ASLK KYFL ITFF LFSF AIGF YLLL KGLG VDLL WTLE KAQR WCEQ PEWV HIDT TPFA SLLK NLGT LFGL GLAL NSSM YRES CKGK LSKW LPFR LSSI V |
| Gene ID: | 2538 |
| Cellular Location: | |
| Calculated MW: | 40KDa |
| Observed MW: | 40KDa |
| Synonyms: | G6PC, G6PT, GSD1, GSD1a, G6Pase |
| Uniprot: | P35575 |
| Background: | Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys. |
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