FZD5/FZD8 Antibody (PACO05446)
- SKU:
- PACO05446
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FZD5/FZD8 Antibody (PACO05446) |
| Antibody SKU: | PACO05446 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the N-terminal region of human Frizzled-5/8. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | FZD5; C2orf31; Frizzled-5; Fz-5; hFz5; FzE5; FZD8; Frizzled-8; Fz-8; hFz8 |
| UniProt Protein Function: | FZD5: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. Interacts with GOPC. Belongs to the G-protein coupled receptor Fz/Smo family. |
| UniProt Protein Details: | Protein type:GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 2q33.3 Cellular Component: cell surface; early endosome membrane; plasma membrane Molecular Function:beta-amyloid binding; protein binding; protein kinase binding; ubiquitin protein ligase binding; Wnt receptor activity; Wnt-protein binding Biological Process: determination of anterior/posterior axis, embryo; embryonic axis specification; neuron differentiation; positive regulation of interferon-gamma production; positive regulation of T cell cytokine production; positive regulation of transcription from RNA polymerase II promoter; Spemann organizer formation; synaptogenesis; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, calcium modulating pathway; Wnt receptor signaling pathway, planar cell polarity pathway |
| NCBI Summary: | Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13467 |
| NCBI GenInfo Identifier: | 116242481 |
| NCBI Gene ID: | 7855 |
| NCBI Accession: | Q13467.2 |
| UniProt Secondary Accession: | Q13467,Q53R22, A8K2X1, B2RCZ1, |
| UniProt Related Accession: | Q13467 |
| Molecular Weight: | 65kDa |
| NCBI Full Name: | Frizzled-5 |
| NCBI Synonym Full Names: | frizzled class receptor 5 |
| NCBI Official Symbol: | FZD5 |
| NCBI Official Synonym Symbols: | HFZ5; C2orf31 |
| NCBI Protein Information: | frizzled-5 |
| UniProt Protein Name: | Frizzled-5 |
| UniProt Synonym Protein Names: | FzE5 |
| Protein Family: | Frizzled |
| UniProt Gene Name: | FZD5 |
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