FXR/NR1H4 Monoclonal Antibody
- SKU:
- CAB24015
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | FXR/NR1H4 Monoclonal Antibody |
| Product Code: | CAB24015 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC62920 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Hep G2 |
| Cellular Location: | Nucleus |
This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human FXR/NR1H4 (NP_001193922.1). |
| Sequence: | CKSKR LRKNV KQHAD QTVNE DSEGR DLRQV TSTTK SCREK TELTP DQQTL LHFIM DSYNK QRMPQ EITNK ILKEE FSAEE NFLIL TEMAT NHVQV LVEFT KKLPG FQTLD HEDQI ALLKG SAVEA MFLRS AEIFN KKLPS GHSDL LEERI RNSGI SDEYI TPMFS FYKSI GELKM TQEEY ALLTA IVILS PDRQY IKDRE AVEKL QEPLL DVLQK LCKIH QPENP QHFAC LLGRL TELRT FNHHH AEMLM SWRVN DHKFT PLLCE IWDVQ |
| Synonyms: | BAR, FXR, HRR1, HRR-1, PFIC5, RIP14 |
| Calculated MW: | 48kDa, 54kDa, 55kDa, 56kDa |
| Observed MW: | 57kDa |
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