Fumarase Monoclonal Antibody [PAT3F6AT] (CPAB0205)
![Fumarase Monoclonal Antibody [PAT3F6AT] (CPAB0205)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58431/63613/fumarase-monoclonal-antibody-pat3f6at-cpab0205__25184__18644.1706535009.jpg?c=1 "Fumarase Monoclonal Antibody [PAT3F6AT] (CPAB0205)")
- SKU:
- CPAB0205
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG2a
- Clone:
- PAT3F6AT
- Applications:
- WB
- Applications:
- ELISA
- Applications:
- FC
![Fumarase Monoclonal Antibody [PAT3F6AT] (CPAB0205)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58431/63613/fumarase-monoclonal-antibody-pat3f6at-cpab0205__25184__18644.1706535009.jpg?c=1&imbypass=on "Fumarase Monoclonal Antibody [PAT3F6AT] (CPAB0205)")
Description
system_update_alt Datasheet
| Product Name: | Fumarase Antibody |
| Product Sku: | CPAB0205 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human Fumarase mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human Fumarase amino acids 44-51 purified from Ecoli. |
| Clone: | PAT3F6AT. |
| Reactivity: | Human |
| Applications: | Western Blot, ELISA, Flow Cytometry |
| Purification Method: | Fumarase antibody was purified from mouse ascitic fluids by protein-A affinity chromatography. |
| Isotype: | IgG2a |
| Background: | Fumarase is an enzymatic factor of Krebs cycle, which catalyzes the formation of L-malate from fumarate. Fumarase exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is aimed to the mitochondrion, where the removal of the extension results in the same form as in the cytoplasm. Fumarase is similar to a number of thermostable Class-2 fumarases and functions as a homotetramer. Mutations in the Fumarase gene causes fumarase deficiency and leads to progressive encephalopathy, cerebral atrophy and developmental delay. Fumarase enzyme is also thought to act as a tumor suppressor. Leydig cell tumors are caused by Fumarase mutations and represents one of the first reports of germline mutations in any type of adult testicular tumor. |
| Synonyms: | MCL, LRCC, HLRCC, MCUL1, FH, Fumarate hydratase, Fumarase. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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