Fumarase Monoclonal Antibody [PAT3F6AT] (CPAB0205)

Name: Fumarase Monoclonal Antibody [PAT3F6AT] (CPAB0205)
SKU: CPAB0205
Availability: OutOfStock

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system_update_alt Datasheet Overview

system_update_alt Datasheet Overview

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Product Name:	Fumarase Antibody
Product Sku:	CPAB0205
Size:	5μg
Host Species:	Mouse
Immunogen:	Anti-human Fumarase mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human Fumarase amino acids 44-51 purified from Ecoli.
Clone:	PAT3F6AT.
Reactivity:	Human
Applications:	Western Blot, ELISA, Flow Cytometry

Purification Method:	Fumarase antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:	IgG2a
Background:	Fumarase is an enzymatic factor of Krebs cycle, which catalyzes the formation of L-malate from fumarate. Fumarase exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is aimed to the mitochondrion, where the removal of the extension results in the same form as in the cytoplasm. Fumarase is similar to a number of thermostable Class-2 fumarases and functions as a homotetramer. Mutations in the Fumarase gene causes fumarase deficiency and leads to progressive encephalopathy, cerebral atrophy and developmental delay. Fumarase enzyme is also thought to act as a tumor suppressor. Leydig cell tumors are caused by Fumarase mutations and represents one of the first reports of germline mutations in any type of adult testicular tumor.
Synonyms:	MCL, LRCC, HLRCC, MCUL1, FH, Fumarate hydratase, Fumarase.
Storage Buffer:	For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.