Antibody Name:	Fuca1 Antibody (PACO53890)
Antibody SKU:	PACO53890
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:	Mouse, Rat
Immunogen:	Recombinant Mouse Tissue alpha-L-fucosidase protein (18-452AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Western Blot. Positive WB detected in: Rat kideny tissue. All lanes: Fuca1 antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 53 kDa. Observed band size: 53 kDa.

Background:	Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
Synonyms:	Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1), Fuca1, Fuca

UniProt Protein Function:	FUCA1: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins. Defects in FUCA1 are the cause of fucosidosis (FUCA1D). FUCA1D is an autosomal recessive lysosomal storage disease characterized by accumulation of fucose-containing glycolipids and glycoproteins in various tissues. Clinical signs include facial dysmorphism, dysostosis multiplex, moderate hepatomegaly, severe intellectual deficit, deafness, and according to age, angiokeratomas. Belongs to the glycosyl hydrolase 29 family.
UniProt Protein Details:	Protein type:EC 3.2.1.51; Glycan Metabolism - other glycan degradation; Hydrolase Chromosomal Location of Human Ortholog: 4 D3\|4 68.01 cM Cellular Component: lysosome Molecular Function:alpha-L-fucosidase activity; carbohydrate binding; fucosidase activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds Biological Process: carbohydrate metabolic process; fucose metabolic process; glycoside catabolic process; metabolic process
UniProt Code:	Q99LJ1
NCBI GenInfo Identifier:	169808427
NCBI Gene ID:	71665
NCBI Accession:	NP_077205.3
UniProt Secondary Accession:	Q99LJ1,Q3UAH8, Q8BN13, Q9DD22, B1AV51,
UniProt Related Accession:	Q99LJ1
Molecular Weight:	52,281 Da
NCBI Full Name:	tissue alpha-L-fucosidase
NCBI Synonym Full Names:	fucosidase, alpha-L- 1, tissue
NCBI Official Symbol:	Fuca1
NCBI Official Synonym Symbols:	Afuc; Fuca; 0610006A03Rik; 9530055J05Rik
NCBI Protein Information:	tissue alpha-L-fucosidase
UniProt Protein Name:	Tissue alpha-L-fucosidase
UniProt Synonym Protein Names:	Alpha-L-fucosidase I; Alpha-L-fucoside fucohydrolase 1; Alpha-L-fucosidase 1
Protein Family:	Tissue alpha-L-fucosidase
UniProt Gene Name:	Fuca1