| UniProt Protein Function: | FRS3: Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 6p21.1Cellular Component: plasma membraneMolecular Function: protein binding; insulin receptor binding; fibroblast growth factor receptor bindingBiological Process: fibroblast growth factor receptor signaling pathway; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013] |
| UniProt Code: | O43559 |
| NCBI GenInfo Identifier: | 5730059 |
| NCBI Gene ID: | 10817 |
| NCBI Accession: | NP_006644.1 |
| UniProt Secondary Accession: | O43559,Q5T3D5 |
| UniProt Related Accession: | O43559 |
| Molecular Weight: | 54,462 Da |
| NCBI Full Name: | fibroblast growth factor receptor substrate 3 |
| NCBI Synonym Full Names: | fibroblast growth factor receptor substrate 3 |
| NCBI Official Symbol: | FRS3 |
| NCBI Official Synonym Symbols: | SNT2; FRS2B; SNT-2; FRS2beta; FRS2-beta |
| NCBI Protein Information: | fibroblast growth factor receptor substrate 3; FGFR substrate 3; FGFR-signaling adaptor SNT2; suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor) |
| UniProt Protein Name: | Fibroblast growth factor receptor substrate 3 |
| UniProt Synonym Protein Names: | FGFR-signaling adaptor SNT2; Suc1-associated neurotrophic factor target 2; SNT-2 |
| Protein Family: | Fibroblast growth factor receptor substrate |
| UniProt Gene Name: | FRS3 |
| UniProt Entry Name: | FRS3_HUMAN |
