FOXN4 Antibody (PACO22335)
- SKU:
- PACO22335
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FOXN4 Antibody (PACO22335) |
| Antibody SKU: | PACO22335 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human FOXN4. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from LOVO cells, using FOXN4 antibody. |
| Background: | Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development By similarity. |
| Synonyms: | Forkhead box protein N4; FOXN4; |
| UniProt Protein Function: | FOXN4: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell development/differentiation; DNA-binding; Transcription factorChromosomal Location of Human Ortholog: 12q24.11Cellular Component: nucleusMolecular Function: chromatin binding; transcription factor activityBiological Process: heart looping; positive regulation of transcription, DNA-dependent; regulation of heart contraction; regulation of transcription, DNA-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q96NZ1 |
| NCBI GenInfo Identifier: | 71153520 |
| NCBI Gene ID: | 121643 |
| NCBI Accession: | Q96NZ1.2 |
| UniProt Secondary Accession: | Q96NZ1,Q6ZMR4, Q96NZ0 |
| UniProt Related Accession: | Q96NZ1 |
| Molecular Weight: | 36,025 Da |
| NCBI Full Name: | Forkhead box protein N4 |
| NCBI Synonym Full Names: | forkhead box N4 |
| NCBI Official Symbol: | FOXN4 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | forkhead box protein N4 |
| UniProt Protein Name: | Forkhead box protein N4 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Forkhead box protein |
| UniProt Gene Name: | FOXN4 |
| UniProt Entry Name: | FOXN4_HUMAN |
| Antibodies |
| FOXN4 Antibody (PACO02453) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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