FOXN1 Antibody (PACO49598)
- SKU:
- PACO49598
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FOXN1 Antibody (PACO49598) |
| Antibody SKU: | PACO49598 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Forkhead box protein N1 protein (1-160AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Raji whole cell lysate, Mouse lung tissue, Mouse stomach tissue. All lanes: FOXN1 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 69 kDa. Observed band size: 69 kDa.. |
 | Immunohistochemistry of paraffin-embedded human cervical cancer using PACO49598 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO49598 at dilution of 1:100. |
| Background: | Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny. |
| Synonyms: | Forkhead box protein N1 (Winged-helix transcription factor nude), FOXN1, RONU WHN |
| UniProt Protein Function: | FOXN1: Transcriptional regulator involved in development. Defects in FOXN1 are the cause of T-cell immunodeficiency congenital alopecia and nail dystrophy (TIDAND). A disorder characterized by the association of congenital alopecia, severe T-cell immunodeficiency, and ridging and pitting of all nails.Protein type: DNA-binding; Transcription factor; Cell development/differentiationChromosomal Location of Human Ortholog: 17q11.2Biological Process: defense response; epidermis development; organ morphogenesis; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoterDisease: T-cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy |
| UniProt Protein Details: | |
| NCBI Summary: | Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15353 |
| NCBI GenInfo Identifier: | 13124629 |
| NCBI Gene ID: | 8456 |
| NCBI Accession: | O15353.1 |
| UniProt Secondary Accession: | O15353,O15352, B2R9Q7 |
| UniProt Related Accession: | O15353 |
| Molecular Weight: | 68,925 Da |
| NCBI Full Name: | Forkhead box protein N1 |
| NCBI Synonym Full Names: | forkhead box N1 |
| NCBI Official Symbol: | FOXN1 |
| NCBI Official Synonym Symbols: | WHN; RONU; FKHL20 |
| NCBI Protein Information: | forkhead box protein N1 |
| UniProt Protein Name: | Forkhead box protein N1 |
| UniProt Synonym Protein Names: | Winged-helix transcription factor nude |
| Protein Family: | Forkhead box protein |
| UniProt Gene Name: | FOXN1 |
| UniProt Entry Name: | FOXN1_HUMAN |
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