FOXD3 Transcription Factor Activity Assay
- SKU:
- TFAB00109
- Product Type:
- ELISA Kit
- ELISA Type:
- Transcription Factor Assay
- Analytes:
- FOXD3
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
Description
| Product Name: | FOXD3 Transcription Factor Activity Assay |
| Product Code: | TFAB00109 |
| Target: | FOXD3 |
| Synonyms: | HNF3/FH transcription factor genesis |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie FOXD3 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | FOXD3: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 1p31.3 Cellular Component: nucleoplasm; nuclear chromatin Molecular Function:protein binding; double-stranded DNA binding; transcription factor activity Biological Process: embryonic placenta development; transcription, DNA-dependent; somatic stem cell maintenance; in utero embryonic development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; trophectodermal cell differentiation Disease: Autoimmune Disease, Susceptibility To, 1 |
| NCBI Summary: | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008] |
| UniProt Code: | Q9UJU5 |
| NCBI GenInfo Identifier: | 8134475 |
| NCBI Gene ID: | 27022 |
| NCBI Accession: | Q9UJU5.1 |
| UniProt Secondary Accession: | Q9UJU5,Q9BYM2, Q9UDD1, |
| UniProt Related Accession: | Q9UJU5 |
| Molecular Weight: | 478 |
| NCBI Full Name: | Forkhead box protein D3 |
| NCBI Synonym Full Names: | forkhead box D3 |
| NCBI Official Symbol: | FOXD3 |
| NCBI Official Synonym Symbols: | AIS1; HFH2; VAMAS2; Genesis |
| NCBI Protein Information: | forkhead box protein D3; HNF3/FH transcription factor genesis |
| UniProt Protein Name: | Forkhead box protein D3 |
| UniProt Synonym Protein Names: | HNF3/FH transcription factor genesis |
| Protein Family: | Forkhead box protein |
| UniProt Gene Name: | FOXD3 |
| UniProt Entry Name: | FOXD3_HUMAN |
