FNBP1L Antibody (PACO09330)
- SKU:
- PACO09330
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FNBP1L Antibody (PACO09330) |
| Antibody SKU: | PACO09330 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human FNBP1L |
| Form: | Liquid |
| Storage Buffer: | 0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | formin binding protein 1-like;FNBP1L;C1orf39;TOCA1 ; |
| UniProt Protein Function: | FNBP1L: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. Belongs to the FNBP1 family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 1p22.1Cellular Component: cytoplasm; cytoplasmic membrane-bound vesicle; trans-Golgi networkMolecular Function: ARF guanyl-nucleotide exchange factor activity; protein bindingBiological Process: cilium biogenesis; membrane budding; membrane invagination; positive regulation of filopodium formation; vesicle organization and biogenesis; vesicle transport along actin filament |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q5T0N5 |
| NCBI GenInfo Identifier: | 663434119 |
| NCBI Gene ID: | 54874 |
| NCBI Accession: | Q5T0N5.3 |
| UniProt Secondary Accession: | Q5T0N5,Q5T0N6, Q6B097, Q6P653, Q6R4Q4, Q9NXG1, J3QSS4 |
| UniProt Related Accession: | Q5T0N5 |
| Molecular Weight: | 69,894 Da |
| NCBI Full Name: | Formin-binding protein 1-like |
| NCBI Synonym Full Names: | formin binding protein 1 like |
| NCBI Official Symbol: | FNBP1L |
| NCBI Official Synonym Symbols: | TOCA1; C1orf39 |
| NCBI Protein Information: | formin-binding protein 1-like |
| UniProt Protein Name: | Formin-binding protein 1-like |
| UniProt Synonym Protein Names: | Transducer of Cdc42-dependent actin assembly protein 1; Toca-1 |
| Protein Family: | Formin-binding protein |
| UniProt Gene Name: | FNBP1L |
| UniProt Entry Name: | FBP1L_HUMAN |
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