FMO4 Antibody (PACO26801)
- SKU:
- PACO26801
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FMO4 Antibody (PACO26801) |
| Antibody SKU: | PACO26801 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Dimethylaniline monooxygenase [N-oxide-forming] 4 protein (1-300AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO26801 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO26801 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. |
| Synonyms: | Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC 1.14.13.8) (Dimethylaniline oxidase 4) (Hepatic flavin-containing monooxygenase 4) (FMO 4), FMO4, FMO2 |
| UniProt Protein Function: | FMO4: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Belongs to the FMO family.Protein type: Membrane protein, integral; EC 1.14.13.8; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450Chromosomal Location of Human Ortholog: 1q24.3Cellular Component: endoplasmic reticulum membrane; integral to membraneMolecular Function: FAD binding; NADP binding; flavin-containing monooxygenase activityBiological Process: drug catabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Sep 2013] |
| UniProt Code: | P31512 |
| NCBI GenInfo Identifier: | 399506 |
| NCBI Gene ID: | 2329 |
| NCBI Accession: | P31512.3 |
| UniProt Secondary Accession: | P31512,Q53XR0 |
| UniProt Related Accession: | P31512 |
| Molecular Weight: | 63,343 Da |
| NCBI Full Name: | Dimethylaniline monooxygenase |
| NCBI Synonym Full Names: | flavin containing monooxygenase 4 |
| NCBI Official Symbol: | FMO4 |
| NCBI Official Synonym Symbols: | FMO2 |
| NCBI Protein Information: | dimethylaniline monooxygenase [N-oxide-forming] 4; dimethylaniline monooxygenase [N-oxide-forming] 4; FMO 4; dimethylaniline oxidase 4; hepatic flavin-containing monooxygenase 4 |
| UniProt Protein Name: | Dimethylaniline monooxygenase [N-oxide-forming] 4 |
| UniProt Synonym Protein Names: | Dimethylaniline oxidase 4; Hepatic flavin-containing monooxygenase 4; FMO 4 |
| Protein Family: | Dimethylaniline monooxygenase |
| UniProt Gene Name: | FMO4 |
| UniProt Entry Name: | FMO4_HUMAN |
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