FMO1 Antibody (PACO44477)
- SKU:
- PACO44477
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FMO1 Antibody (PACO44477) |
| Antibody SKU: | PACO44477 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Dimethylaniline monooxygenase [N-oxide-forming] 1 protein (363-532AA) |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO44477 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO44477 at dilution of 1:100. |
| Background: | This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines. |
| Synonyms: | Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC 1.14.13.8) (Dimethylaniline oxidase 1) (Fetal hepatic flavin-containing monooxygenase 1) (FMO 1), FMO1 |
| UniProt Protein Function: | FMO1: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines. Belongs to the FMO family. |
| UniProt Protein Details: | Protein type:EC 1.14.13.8; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450 Chromosomal Location of Human Ortholog: 1q24.3 Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen; integral to membrane Molecular Function:FAD binding; NADP binding; monooxygenase activity; flavin-containing monooxygenase activity Biological Process: organic acid metabolic process; toxin metabolic process; xenobiotic metabolic process; response to lipopolysaccharide; response to osmotic stress; drug metabolic process |
| NCBI Summary: | Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q01740 |
| NCBI GenInfo Identifier: | 399505 |
| NCBI Gene ID: | 2326 |
| NCBI Accession: | Q01740.3 |
| UniProt Secondary Accession: | Q01740,Q5QPT2, Q9UJC2, A8K248, B7Z3P4, |
| UniProt Related Accession: | Q01740 |
| Molecular Weight: | 532 |
| NCBI Full Name: | Dimethylaniline monooxygenase |
| NCBI Synonym Full Names: | flavin containing monooxygenase 1 |
| NCBI Official Symbol: | FMO1 |
| NCBI Protein Information: | dimethylaniline monooxygenase [N-oxide-forming] 1; dimethylaniline monooxygenase [N-oxide-forming] 1; FMO 1; dimethylaniline oxidase 1; Flavin-containing monooxygenase 1 (fetal liver); fetal hepatic flavin-containing monooxygenase 1 |
| UniProt Protein Name: | Dimethylaniline monooxygenase [N-oxide-forming] 1 |
| UniProt Synonym Protein Names: | Dimethylaniline oxidase 1; Fetal hepatic flavin-containing monooxygenase 1; FMO 1 |
| Protein Family: | Thiol-specific monooxygenase |
| UniProt Gene Name: | FMO1 |
| UniProt Entry Name: | FMO1_HUMAN |
| Antibodies |
| Anti-FMO1 Antibody (CAB6908) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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