FMNL3 Antibody (PACO46786)
- SKU:
- PACO46786
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FMNL3 Antibody (PACO46786) |
| Antibody SKU: | PACO46786 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Formin-like protein 3 protein (2-212AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO46786 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO46786 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO46786 at dilution of 1:100. |
| Background: | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement. |
| Synonyms: | Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3), FMNL3, FHOD3 FRL2 KIAA2014 WBP3 |
| UniProt Protein Function: | FMNL3: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Belongs to the formin homology family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 12q13.12Cellular Component: cytoplasmMolecular Function: Rho GTPase binding; GTPase activating protein binding; actin bindingBiological Process: regulation of cell shape; cell migration; cytoskeleton organization and biogenesis; actin cytoskeleton organization and biogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8IVF7 |
| NCBI GenInfo Identifier: | 119120874 |
| NCBI Gene ID: | 91010 |
| NCBI Accession: | NP_783863.4 |
| UniProt Secondary Accession: | Q8IVF7,Q6ZRJ1, B0JZA7 |
| UniProt Related Accession: | Q8IVF7 |
| Molecular Weight: | 116,871 Da |
| NCBI Full Name: | formin-like protein 3 isoform 1 |
| NCBI Synonym Full Names: | formin-like 3 |
| NCBI Official Symbol: | FMNL3 |
| NCBI Official Synonym Symbols: | FRL2; WBP3; FHOD3; WBP-3 |
| NCBI Protein Information: | formin-like protein 3; WW domain binding protein 3; formin homology 2 domain-containing protein 3 |
| UniProt Protein Name: | Formin-like protein 3 |
| UniProt Synonym Protein Names: | Formin homology 2 domain-containing protein 3; WW domain-binding protein 3; WBP-3 |
| Protein Family: | Formin-like protein |
| UniProt Gene Name: | FMNL3 |
| UniProt Entry Name: | FMNL3_HUMAN |
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