Name: FLT3LG Antibody (PACO26793)
SKU: PACO26793
Availability: OutOfStock

Antibody Name:	FLT3LG Antibody (PACO26793)
Antibody SKU:	PACO26793
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, IHC, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:500-1:1000, IF:1:200-1:500
Species Reactivity:	Human
Immunogen:	Recombinant Human Fms-related tyrosine kinase 3 ligand protein (27-184AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

IHC image of PACO26793 diluted at 1:800 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of MCF-7 cells with PACO26793 at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Background:	Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
Synonyms:	Fms-related tyrosine kinase 3 ligand (Flt3 ligand) (Flt3L) (SL cytokine), FLT3LG

UniProt Protein Function:	FLT3LG: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Cytokine; Ligand, receptor tyrosine kinase; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: extracellular space; membrane; integral to membrane Molecular Function:protein homodimerization activity; cytokine activity; receptor tyrosine kinase binding; receptor binding Biological Process: regulation of myeloid dendritic cell activation; positive regulation of natural killer cell differentiation; lymphocyte differentiation; embryonic hemopoiesis; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; signal transduction; positive regulation of myoblast differentiation
NCBI Summary:	Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]
UniProt Code:	P49771
NCBI GenInfo Identifier:	1706818
NCBI Gene ID:	2323
NCBI Accession:	P49771.1
UniProt Secondary Accession:	P49771,Q05C96, A0AVC2, B9EGH2,
UniProt Related Accession:	P49771
Molecular Weight:	approximately 150 kDa
NCBI Full Name:	Fms-related tyrosine kinase 3 ligand
NCBI Synonym Full Names:	fms-related tyrosine kinase 3 ligand
NCBI Official Symbol:	FLT3LG
NCBI Official Synonym Symbols:	FL; FLT3L
NCBI Protein Information:	fms-related tyrosine kinase 3 ligand; flt3 ligand
UniProt Protein Name:	Fms-related tyrosine kinase 3 ligand
UniProt Synonym Protein Names:	SL cytokine
Protein Family:	Receptor-type tyrosine-protein kinase
UniProt Gene Name:	FLT3LG
UniProt Entry Name:	FLT3L_HUMAN

Antibodies	ELISA Kits
FLT3LG Antibody (PACO00811)	Human FLT3L / FMS Like Tyrosine Kinase 3 Ligand ELISA Kit
FLT3LG Antibody (PACO02184)	Human Flt3L (FMS Like Tyrosine Kinase 3 Ligand) CLIA Kit (HUES00073)
	Human Flt3L (FMS Like Tyrosine Kinase 3 Ligand) ELISA Kit (HUES01362)
	Human Fms-related tyrosine kinase 3 ligand (FLT3LG) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)