Flt3/CD135 Monoclonal Antibody (CAB24344)

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SKU:
CAB24344
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
IHC
Applications:
FC

Description

Product Name:Flt3/CD135 Monoclonal Antibody
Product Code:CAB24344
Reactivity:Human, Mouse, Rat
Applications:Immunohistochemistry, Flow Cytometry
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC63041
Reactivity:Human, Mouse, Rat
Tested Applications:IHC-P, FC, ELISA
Key Applications:Immunohistochemistry, Flow Cytometry
Recommended Dilution:IHC 1:50-1:200, FC 1:100-1:500
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Cellular Location:Endoplasmic reticulum lumen, Membrane, Single-pass type I membrane protein

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-163 of human Flt3/CD135 (NP_004110.2).
Sequence:NQDLP VIKCV LINHK NNDSS VGKSS SYPMV SESPE DLGCA LRPQS SGTVY EAAAV EVDVS ASITL QVLVD APGNI SCLWV FKHSS LNCQP HFDLQ NRGVV SMVIL KMTET QAGEY LLFIQ SEATN YTILF TVSIR NT
Synonyms:FLK2, STK1, CD135, FLK-2
Calculated MW:113kDa
Observed MW:Refer to figures
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