FLG Monoclonal Antibody
- SKU:
- CAB23193
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | FLG Monoclonal Antibody |
| Product Code: | CAB23193 |
| Reactivity: | Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC60254 |
| Reactivity: | Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse stomach, Rat stomach |
| Cellular Location: | Cytoplasmic ribonucleoprotein granule, Cytosol, keratohyalin granule, Nucleus |
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-92AA of human FLG (NP_002007.1). |
| Sequence: | MSTLL ENIFA IINLF KQYSK KDKNT DTLSK KELKE LLEKE FRQIL KNPDD PDMVD VFMDH LDIDH NKKID FTEFL LMVFK LAQAY YESTR KE |
| Synonyms: | FLG1, ATOD2, FLG-1 |
| Calculated MW: | 435kDa |
| Observed MW: | 50kDa |
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