FITC Anti-Human/Mouse KLRG-1 Antibody [2F1] (AGEL3130)
- SKU:
- AGEL3130
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Applications:
- FCM
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Syrian Hamster
- Isotype:
- Syrian Hamster IgG
- Clone:
- 2F1
- Conjugation:
- FITC
Description
| Product Name: | FITC Anti-Human/Mouse KLRG-1 Antibody [2F1] (AGEL3130) |
| Product Code: | AGEL3130 |
| Clone No: | 2F1 |
| Synonyms: | MAFA, 2F1-Ag |
| Reactivity: | Human,Mouse |
| Host Species: | Syrian Hamster |
| Applications: | FCM |
| Isotype: | Syrian Hamster IgG |
| Isotype Control: | PE Armenian Hamster IgG Isotype Control [PIP] (AGEL2690) |
| Conjugation: | FITC |
| Form: | Liquid |
| Fluorescent Label: | FITC is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 530 nm (e.g., a 525/40 nm bandpass filter). |
| Recommended Use: | Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume]. |
| Storage Buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Gene ID: | 1021950928 |
| Swissprot: | Q96E93,O88713 |
| Stability & Storage: | Keep as concentrated solution. Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
| Shipping: | Biological ice pack at 4°C |
Killer cell lectin-like receptor G1 (KLRG1) is the mouse homolog of the rat mast cell function-associated antigen (MAFA or 2F1-Ag). KLRG1 is a type II membrane glycoprotein that was first identified on the surface of rat mast cell line RBL-2H3. It is composed of a homodimer of glycosylated 30-38 kD subunits. Mouse and human homologs of KLRG1 are expressed by subsets of NK cells and lymphokine-activated killer (LAK) cells but not mast cells. KLRG1 is also expressed on subsets of CD8+ and CD4+ cells, including CD4+ and CD8+ effector/memory cells, potent regulatory CD4+ T cells. KLRG1 may be involved in regulating NK cell homeostasis. KLRG20 was found to recognize cadherins and thus inhibit immune responses by regulating the effector function and the developmental processes of NK and T cells.
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