Fibroblast activation protein-α (FAP) Monoclonal Antibody
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- SKU:
- CAB23789
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | Fibroblast activation protein-α (FAP) Monoclonal Antibody |
| Product Code: | CAB23789 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC61700 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | U-87MG, Rat uterus |
| Cellular Location: | Cell membrane, Cell projection, Cell surface, Cytoplasm, Membrane, Secreted, Single-pass type II membrane protein, Single-pass type II membrane protein, invadopodium membrane, lamellipodium membrane, ruffle membrane |
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 411-510 of human FAP (NP_004451.2). |
| Sequence: | SSNEF EEYPG RRNIY RISIG SYPPS KKCVT CHLRK ERCQY YTASF SDYAK YYALV CYGPG IPIST LHDGR TDQEI KILEE NKELE NALKN IQLPK EEIKK |
| Synonyms: | FAP, DPPIV, FAPA, FAPalpha, SIMP, prolyl endopeptidase FAP |
| Calculated MW: | 26kDa/87kDa |
| Observed MW: | 95kDa |
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