Name: FGFRL1 Antibody (PACO56796)
SKU: PACO56796
Availability: OutOfStock

Antibody Name:	FGFRL1 Antibody (PACO56796)
Antibody SKU:	PACO56796
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, IHC, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:500-1:1000, IF:1:50-1:200
Species Reactivity:	Human
Immunogen:	Recombinant Human Fibroblast growth factor receptor-like 1 protein (403-470AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	IHC image of PACO56796 diluted at 1:500 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
	Immunofluorescence staining of Hela cells with PACO56796 at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
	IHC image of PACO56796 diluted at 1:500 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Background:	Has a negative effect on cell proliferation.
Synonyms:	Fibroblast growth factor receptor-like 1 (FGF receptor-like protein 1) (FGF homologous factor receptor) (FGFR-like protein) (Fibroblast growth factor receptor 5) (FGFR-5), FGFRL1, FGFR5 FHFR

UniProt Protein Function:	FGFRL1: Has a negative effect on cell proliferation.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 4p16Cellular Component: Golgi apparatus; plasma membrane; transport vesicleMolecular Function: fibroblast growth factor receptor activity; heparin bindingBiological Process: fibroblast growth factor receptor signaling pathway; protein heterooligomerization; protein homooligomerizationDisease: Wolf-hirschhorn Syndrome
UniProt Protein Details:
NCBI Summary:	The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	Q8N441
NCBI GenInfo Identifier:	68052359
NCBI Gene ID:	53834
NCBI Accession:	Q8N441.1
UniProt Secondary Accession:	Q8N441,Q6PJN1, Q9BXN7, Q9H4D7, B2RAU9
UniProt Related Accession:	Q8N441
Molecular Weight:	54,537 Da
NCBI Full Name:	Fibroblast growth factor receptor-like 1
NCBI Synonym Full Names:	fibroblast growth factor receptor-like 1
NCBI Official Symbol:	FGFRL1
NCBI Official Synonym Symbols:	FHFR; FGFR5
NCBI Protein Information:	fibroblast growth factor receptor-like 1
UniProt Protein Name:	Fibroblast growth factor receptor-like 1
UniProt Synonym Protein Names:	FGF homologous factor receptor; FGFR-like protein; Fibroblast growth factor receptor 5; FGFR-5
Protein Family:	Fibroblast growth factor receptor
UniProt Gene Name:	FGFRL1
UniProt Entry Name:	FGRL1_HUMAN