Antibody Name:	FGF16 Antibody (PACO19656)
Antibody SKU:	PACO19656
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human FGF16

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19656(FGF16 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19656(FGF16 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The rat homolog is predominantly expressed in embryonic brown adipose tissue and has significant mitogenic activity, which suggests a role in proliferation of embryonic brown adipose tissue.

Synonyms:

fibroblast growth factor 16

UniProt Protein Function:	FGF16: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. Belongs to the heparin-binding growth factors family.Protein type: CytokineChromosomal Location of Human Ortholog: Xq13Cellular Component: extracellular region; extracellular spaceMolecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activityBiological Process: cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; metabolic process; organ morphogenesis; phosphoinositide-mediated signaling; regulation of endothelial cell proliferation; regulation of MAP kinase activity; regulation of phosphoinositide 3-kinase cascade; response to temperature stimulus; signal transductionDisease: Metacarpal 4-5 Fusion
UniProt Protein Details:
NCBI Summary:	This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014]
UniProt Code:	O43320
NCBI GenInfo Identifier:	6015145
NCBI Gene ID:	8823
NCBI Accession:	O43320.1
UniProt Secondary Accession:	O43320
UniProt Related Accession:	O43320
Molecular Weight:	23,759 Da
NCBI Full Name:	Fibroblast growth factor 16
NCBI Synonym Full Names:	fibroblast growth factor 16
NCBI Official Symbol:	FGF16
NCBI Official Synonym Symbols:	MF4; FGF-16
NCBI Protein Information:	fibroblast growth factor 16
UniProt Protein Name:	Fibroblast growth factor 16
UniProt Synonym Protein Names:
Protein Family:	Fibroblast growth factor
UniProt Gene Name:	FGF16
UniProt Entry Name:	FGF16_HUMAN