FGD2 Antibody (PACO09280)
- SKU:
- PACO09280
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FGD2 Antibody (PACO09280) |
| Antibody SKU: | PACO09280 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human FGD2 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | FYVE, RhoGEF and PH domain containing 2;FGD2;FLJ00048;FLJ40929;MGC71330;ZFYVE4 ; |
| UniProt Protein Function: | FGD2: an endosome and ruffle membrane-associated guanine nucleotide exchange factor (GEF) that activates CDC42, a small G protein of the Rho-subfamily. Interacts with RAB6A bound to GTP. Activates JNK1 via CDC42 but not RAC1. Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate. The FYVE-type zinc-finger is necessary for early endosome localization. Recruitment to endosomal membranes via this domain requires the presence of phosphatidylinositol 3-phosphate or other phosphatidylinositides. The PH domain is necessary for localization to the ruffle membrane. Recruitment to ruffle membrane occurs through binding of phosphoinositides by the PH domain. This domain also contributes to the lipid-binding properties of the protein. 4 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs, Rac/Rho; GEFsChromosomal Location of Human Ortholog: 6p21.2Cellular Component: cytoplasm; cytosol; Golgi apparatus; lamellipodium; ruffleMolecular Function: guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity; small GTPase bindingBiological Process: actin cytoskeleton organization and biogenesis; cytoskeleton organization and biogenesis; filopodium formation; positive regulation of apoptosis; regulation of cell shape; regulation of GTPase activity; regulation of small GTPase mediated signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q7Z6J4 |
| NCBI GenInfo Identifier: | 61213572 |
| NCBI Gene ID: | 221472 |
| NCBI Accession: | Q7Z6J4.1 |
| UniProt Secondary Accession: | Q7Z6J4,Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2 |
| UniProt Related Accession: | Q7Z6J4 |
| Molecular Weight: | 13,825 Da |
| NCBI Full Name: | FYVE, RhoGEF and PH domain-containing protein 2 |
| NCBI Synonym Full Names: | FYVE, RhoGEF and PH domain containing 2 |
| NCBI Official Symbol: | FGD2 |
| NCBI Official Synonym Symbols: | ZFYVE4 |
| NCBI Protein Information: | FYVE, RhoGEF and PH domain-containing protein 2 |
| UniProt Protein Name: | FYVE, RhoGEF and PH domain-containing protein 2 |
| UniProt Synonym Protein Names: | Zinc finger FYVE domain-containing protein 4 |
| Protein Family: | FYVE, RhoGEF and PH domain-containing protein |
| UniProt Gene Name: | FGD2 |
| UniProt Entry Name: | FGD2_HUMAN |
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