FBXW10 Antibody (PACO36506)
- SKU:
- PACO36506
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FBXW10 Antibody (PACO36506) |
| Antibody SKU: | PACO36506 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human F-box/WD repeat-containing protein 10 protein (701-1000AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO36506 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human colon tissue using PACO36506 at dilution of 1:100. |
| Background: | Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1. |
| Synonyms: | F-box/WD repeat-containing protein 10 (F-box and WD-40 domain-containing protein 10) (Ubiquitin ligase-specificity factor), FBXW10 |
| UniProt Protein Function: | Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1. |
| UniProt Protein Details: | |
| NCBI Summary: | Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q5XX13 |
| NCBI GenInfo Identifier: | 34192015 |
| NCBI Gene ID: | 10517 |
| NCBI Accession: | BC028364 |
| UniProt Secondary Accession: | Q5XX13,Q8TC00, Q9H0F0, C9JRY8, C9JZD7 |
| UniProt Related Accession: | Q5XX13 |
| Molecular Weight: | |
| NCBI Full Name: | Homo sapiens F-box and WD repeat domain containing 10, mRNA |
| NCBI Synonym Full Names: | F-box and WD repeat domain containing 10 |
| NCBI Official Symbol: | FBXW10 |
| NCBI Official Synonym Symbols: | HREP; Fbw10; SM25H2; SM2SH2 |
| NCBI Protein Information: | F-box/WD repeat-containing protein 10 |
| UniProt Protein Name: | F-box/WD repeat-containing protein 10 |
| UniProt Synonym Protein Names: | F-box and WD-40 domain-containing protein 10; Ubiquitin ligase-specificity factor |
| Protein Family: | F-box/WD repeat-containing protein |
| UniProt Gene Name: | FBXW10 |
| UniProt Entry Name: |
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