FBXO9 Antibody (PACO48794)
- SKU:
- PACO48794
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FBXO9 Antibody (PACO48794) |
| Antibody SKU: | PACO48794 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human F-box only protein 9 protein (13-111AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO48794 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO48794 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1. |
| Synonyms: | F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57), FBXO9, FBX9 VCIA1 |
| UniProt Protein Function: | FBXO9: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin conjugating system; LigaseChromosomal Location of Human Ortholog: 6p12.3-p11.2Cellular Component: cytoplasm; SCF ubiquitin ligase complex; ubiquitin ligase complexMolecular Function: protein binding; ubiquitin-protein ligase activityBiological Process: fat cell differentiation; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; innate immune response; protein ubiquitination; regulation of TOR signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UK97 |
| NCBI GenInfo Identifier: | 13124238 |
| NCBI Gene ID: | 26268 |
| NCBI Accession: | Q9UK97.1 |
| UniProt Secondary Accession: | Q9UK97,O75986, Q59EH8, Q6PKH7, Q9NT57, Q9Y593, A6NFW3 B3KMM6 |
| UniProt Related Accession: | Q9UK97 |
| Molecular Weight: | |
| NCBI Full Name: | F-box only protein 9 |
| NCBI Synonym Full Names: | F-box protein 9 |
| NCBI Official Symbol: | FBXO9 |
| NCBI Official Synonym Symbols: | FBX9; VCIA1; NY-REN-57; dJ341E18.2 |
| NCBI Protein Information: | F-box only protein 9; F-box protein Fbx9; cross-immune reaction antigen 1; renal carcinoma antigen NY-REN-57 |
| UniProt Protein Name: | F-box only protein 9 |
| UniProt Synonym Protein Names: | Cross-immune reaction antigen 1; Renal carcinoma antigen NY-REN-57 |
| Protein Family: | F-box only protein |
| UniProt Gene Name: | FBXO9 |
| UniProt Entry Name: | FBX9_HUMAN |
| Antibodies |
| FBXO9 Antibody (PACO09260) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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