FBXL22 Antibody (PACO47962)
- SKU:
- PACO47962
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FBXL22 Antibody (PACO47962) |
| Antibody SKU: | PACO47962 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human F-box and leucine-rich protein 22 protein (123-229AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse brain tissue, Human placenta tissue. All lanes: FBXL22 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 28 kDa. Observed band size: 28 kDa.. |
 | Immunofluorescent analysis of Hela cells using PACO47962 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO47962 at dilution of 1:100. |
| Background: | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC). |
| Synonyms: | F-box and leucine-rich protein 22, FBXL22 |
| UniProt Protein Function: | FBXL22: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.Chromosomal Location of Human Ortholog: 15q22.31Biological Process: proteasomal ubiquitin-dependent protein catabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the F-box protein family. This F-box protein interacts with S-phase kinase-associated protein 1A and cullin in order to form SCF complexes which function as ubiquitin ligases.[provided by RefSeq, Sep 2010] |
| UniProt Code: | Q6P050 |
| NCBI GenInfo Identifier: | 308044497 |
| NCBI Gene ID: | 283807 |
| NCBI Accession: | NP_976307.2 |
| UniProt Secondary Accession: | Q6P050 |
| UniProt Related Accession: | Q6P050 |
| Molecular Weight: | 27,269 Da |
| NCBI Full Name: | F-box and leucine-rich protein 22 |
| NCBI Synonym Full Names: | F-box and leucine rich repeat protein 22 |
| NCBI Official Symbol: | FBXL22 |
| NCBI Official Synonym Symbols: | Fbl22 |
| NCBI Protein Information: | F-box and leucine-rich protein 22 |
| UniProt Protein Name: | F-box and leucine-rich protein 22 |
| UniProt Synonym Protein Names: | |
| Protein Family: | F-box and leucine-rich protein |
| UniProt Gene Name: | FBXL22 |
| UniProt Entry Name: | FXL22_HUMAN |
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