FBXL21 Antibody (PACO47230)
- SKU:
- PACO47230
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FBXL21 Antibody (PACO47230) |
| Antibody SKU: | PACO47230 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human F-box/LRR-repeat protein 21 protein (78-137AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: FBL21 antibody at 10 µg/ml. Lane 1: Mouse heart tissue. Lane 2: Mouse skeletal muscle tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 49 kDa. Observed band size: 49 kDa.. |
 | Immunofluorescent analysis of HepG2 cells using PACO47230 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human lung cancer using PACO47230 at dilution of 1:100. |
| Background: | Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity). |
| Synonyms: | F-box/LRR-repeat protein 21 (F-box and leucine-rich repeat protein 21) (F-box and leucine-rich repeat protein 3B) (F-box/LRR-repeat protein 3B), FBXL21, FBL21 FBL3 FBXL3B FBXL3P |
| UniProt Protein Function: | FBXL21: Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complex involved in circadian pacemaker function. The SCF(FBXL21) complex acts by mediating ubiquitination and subsequent degradation of CRY1. Probable clock-controlled protein that plays a specific role in suprachiasmatic nucleus, SCN and pacemaker function.Chromosomal Location of Human Ortholog: 5q31Cellular Component: SCF ubiquitin ligase complex; cytosol; nucleus; ubiquitin ligase complexMolecular Function: ubiquitin-protein ligase activityBiological Process: rhythmic process; protein ubiquitination; entrainment of circadian clock by photoperiod |
| UniProt Protein Details: | |
| NCBI Summary: | This locus represents a transcribed pseudogene that is related to genes encoding members of the F-box family of proteins. [provided by RefSeq, Nov 2017] |
| UniProt Code: | Q9UKT6 |
| NCBI GenInfo Identifier: | 148922963 |
| NCBI Gene ID: | 26223 |
| NCBI Accession: | NP_036291 |
| UniProt Secondary Accession: | Q9UKT6 |
| UniProt Related Accession: | Q9UKT6 |
| Molecular Weight: | |
| NCBI Full Name: | |
| NCBI Synonym Full Names: | F-box and leucine rich repeat protein 21, pseudogene |
| NCBI Official Symbol: | FBXL21P |
| NCBI Official Synonym Symbols: | FBL3B; Fbl21; FBXL21; FBXL3B; FBXL3P |
| NCBI Protein Information: | |
| UniProt Protein Name: | F-box/LRR-repeat protein 21 |
| UniProt Synonym Protein Names: | F-box and leucine-rich repeat protein 21; F-box and leucine-rich repeat protein 3B; F-box/LRR-repeat protein 3B |
| Protein Family: | F-box/LRR-repeat protein |
| UniProt Gene Name: | FBXL21 |
| UniProt Entry Name: | FXL21_HUMAN |
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