FBXL20 Antibody (PACO58296)
- SKU:
- PACO58296
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FBXL20 Antibody (PACO58296) |
| Antibody SKU: | PACO58296 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human F-box/LRR-repeat protein 20 protein (1-137AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO58296 diluted at 1:800 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). |
| Synonyms: | F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like), FBXL20, FBL2 |
| UniProt Protein Function: | FBXL20: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Role in neural transmission. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 17q12Cellular Component: cytoplasmBiological Process: behavioral fear response |
| UniProt Protein Details: | |
| NCBI Summary: | Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q96IG2 |
| NCBI GenInfo Identifier: | 38503141 |
| NCBI Gene ID: | 84961 |
| NCBI Accession: | Q96IG2.2 |
| UniProt Secondary Accession: | Q96IG2,Q38J52, A8K729 |
| UniProt Related Accession: | Q96IG2 |
| Molecular Weight: | 44,980 Da |
| NCBI Full Name: | F-box/LRR-repeat protein 20 |
| NCBI Synonym Full Names: | F-box and leucine-rich repeat protein 20 |
| NCBI Official Symbol: | FBXL20 |
| NCBI Official Synonym Symbols: | Fbl2; Fbl20 |
| NCBI Protein Information: | F-box/LRR-repeat protein 20; F-box protein FBL2 |
| UniProt Protein Name: | F-box/LRR-repeat protein 20 |
| UniProt Synonym Protein Names: | F-box and leucine-rich repeat protein 20; F-box/LRR-repeat protein 2-like |
| Protein Family: | F-box/LRR-repeat protein |
| UniProt Gene Name: | FBXL20 |
| UniProt Entry Name: | FXL20_HUMAN |
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