FBXL18 Antibody (PACO26697)
- SKU:
- PACO26697
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FBXL18 Antibody (PACO26697) |
| Antibody SKU: | PACO26697 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human F-box/LRR-repeat protein 18 protein (1-365AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO26697 at dilution of 1:100. |
 | Immunofluorescent analysis of A549 cells using PACO26697 at dilution of 1:100 and Cy3-congugated Goat Anti-Rabbit IgG. |
 | Immunohistochemistry of paraffin-embedded human lymphoid tissue using PACO26697 at dilution of 1:100. |
| Background: | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex |
| Synonyms: | F-box/LRR-repeat protein 18 (F-box and leucine-rich repeat protein 18), FBXL18, FBL18 |
| UniProt Protein Function: | FBXL18: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 7p22.1Cellular Component: cytosolMolecular Function: ubiquitin-protein ligase activityBiological Process: post-translational protein modification; protein polyubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016] |
| UniProt Code: | Q96ME1 |
| NCBI GenInfo Identifier: | 61213731 |
| NCBI Gene ID: | 80028 |
| NCBI Accession: | Q96ME1.2 |
| UniProt Secondary Accession: | Q96ME1,Q9BR90, Q9BTC7, Q9HAK7 |
| UniProt Related Accession: | Q96ME1 |
| Molecular Weight: | 56.2kD |
| NCBI Full Name: | F-box/LRR-repeat protein 18 |
| NCBI Synonym Full Names: | F-box and leucine rich repeat protein 18 |
| NCBI Official Symbol: | FBXL18 |
| NCBI Official Synonym Symbols: | Fbl18 |
| NCBI Protein Information: | F-box/LRR-repeat protein 18 |
| UniProt Protein Name: | F-box/LRR-repeat protein 18 |
| UniProt Synonym Protein Names: | F-box and leucine-rich repeat protein 18 |
| Protein Family: | F-box/LRR-repeat protein |
| UniProt Gene Name: | FBXL18 |
| UniProt Entry Name: |
| Antibodies |
| FBXL18 Antibody (PACO09248) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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