Antibody Name:	FAT3 Antibody (PACO19018)
Antibody SKU:	PACO19018
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human FAT3

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19018(FAT3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19018(FAT3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). The atypical cadherin Fat3 ensures that retinal amacrine cells (ACs) develop this unipolar morphology. Fat3 expression was restricted to the nervous system, for example in the brain, it is expressed in a variety of regions and axon fascicles. However, its strongest expression was observed in the olfactory bulb and retina.

Synonyms:

FAT tumor suppressor homolog 3 (Drosophila)

UniProt Protein Function:	FAT3: May play a role in the interactions between neurites derived from specific subsets of neurons during development. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 11q14.3Cellular Component: integral to membrane; plasma membraneMolecular Function: calcium ion bindingBiological Process: multicellular organismal development; homophilic cell adhesion
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q8TDW7
NCBI GenInfo Identifier:	19773541
NCBI Gene ID:
NCBI Accession:	NP_001008781
UniProt Secondary Accession:	Q8TDW7,Q96AU6, B5MDB0
UniProt Related Accession:	Q8TDW7
Molecular Weight:
NCBI Full Name:	fat3, partial
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:	Protocadherin Fat 3
UniProt Synonym Protein Names:	Cadherin family member 15; FAT tumor suppressor homolog 3
Protein Family:	Protocadherin
UniProt Gene Name:	FAT3
UniProt Entry Name:	FAT3_HUMAN