FAS Blocking Monoclonal Antibody [NYRhFAS] (CPAB0045)

(No reviews yet) Write a Review
SKU:
CPAB0045
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
NYRhFAS

Description

system_update_alt Datasheet
Product Name:FAS Blocking Antibody
Product Sku:CPAB0045
Size:500μg
Host Species:mouse
Immunogen:Recombinant Human FAS.
Clone:NYRhFAS.
Reactivity:Human
Applications:
Purification Method:Ion exchange column Protein concentration1 mg/ml in PBS (after reconstitution).
Isotype:IgG1
Background:The Fas receptor (CD95) mediates apoptotic signaling by Fas-ligand expressed on the surface of other cells. The Fas-FasL interaction plays an important role in the immune system and lack of this system leads to autoimmunity, indicating that Fas-mediated apoptosis removes self-reactive lymphocytes. Fas signaling is also involved in immune surveillance to remove transformed cells and virus infected cells. Binding of FAS to oligimerized FasL on another cell activates apoptotic signaling through a cytoplasmic domain termed the death domain that interacts with signaling adaptors including FAF, FADD and DAX to activate the caspase proteolytic cascade. Caspase-8 and caspase-10 are first activated, to then cleave and activate downstream caspases, and a variety of cellular substrates that lead to cell death. Activation of JNK kinase, activation of Jun, and production of ceramide may also play roles in Fas-mediated apoptosis. Activation of fas-mediated apoptosis is opposed by I-FLICE and FAP. Viruses and tumors may escape immune surveillance in part through suppression of fas-mediated apoptosis using similar mechanisms.
Synonyms:FASLG receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, CD95, Tumor necrosis factor receptor superfamily member 6 TNR6, APT1, FAS1, TNFRSF6.
Storage Buffer:In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.
View AllClose

0 Reviews

View AllClose

Related Products

Fas Monoclonal Antibody

Fas Monoclonal Antibody

OverviewProduct Name:Fas Monoclonal AntibodyProduct Code:CAB21903Reactivity:Human, MouseApplications:Western blotting
SPAM1 Monoclonal Antibody

SPAM1 Monoclonal Antibody

OverviewProduct Name:SPAM1 Monoclonal AntibodyProduct Code:CAB22178Reactivity:Human, Mouse, RatApplications:Western blotting, Imm
PMS2 Monoclonal Antibody

PMS2 Monoclonal Antibody

OverviewProduct Name:PMS2 Monoclonal AntibodyProduct Code:CAB22350Reactivity:HumanApplications:Western blotting
ACSL3 Monoclonal Antibody

ACSL3 Monoclonal Antibody

OverviewProduct Name:ACSL3 Monoclonal AntibodyProduct Code:CAB22085Reactivity:Human, Mouse, RatApplications:Western blotting, Imm
NeuroD1 Monoclonal Antibody

NeuroD1 Monoclonal Antibody

OverviewProduct Name:NeuroD1 Monoclonal AntibodyProduct Code:CAB12020Reactivity:MouseApplications:Western blotting<
PRPF4 Monoclonal Antibody

PRPF4 Monoclonal Antibody

OverviewProduct Name:PRPF4 Monoclonal AntibodyProduct Code:CAB21132Reactivity:Human, Mouse, RatApplications:Western blotting, Imm