FARP2 Antibody (PACO21707)
- SKU:
- PACO21707
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FARP2 Antibody (PACO21707) |
| Antibody SKU: | PACO21707 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from Internal of human FIR. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HuvEc cells, using FIR antibody. |
| Background: | Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion By similarity. The MGC Project Team, Genome Res. 14:2121-2127(2004). |
| Synonyms: | FERM; RhoGEF and pleckstrin domain protein 2; FGD1-related Cdc42-GEF; FIR; FRG |
| UniProt Protein Function: | FARP2: Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: cytoplasm; cytoskeleton; cytosol Molecular Function:cytoskeletal protein binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity Biological Process: actin cytoskeleton reorganization; cell adhesion; hair cycle process; neuron remodeling; osteoclast differentiation; positive regulation of GTPase activity; Rac protein signal transduction; regulation of integrin activation; regulation of Rho protein signal transduction |
| UniProt Code: | O94887 |
| NCBI GenInfo Identifier: | 545478372 |
| NCBI Gene ID: | 9855 |
| NCBI Accession: | NP_001269912.1 |
| UniProt Secondary Accession: | O94887,Q53QM5, Q8WU27, Q9UFE7, B7Z6J8, F5GZ84, |
| UniProt Related Accession: | O94887 |
| Molecular Weight: | 119 kDa |
| NCBI Full Name: | FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform b |
| NCBI Synonym Full Names: | FERM, ARH/RhoGEF and pleckstrin domain protein 2 |
| NCBI Official Symbol: | FARP2 |
| NCBI Official Synonym Symbols: | FIR; FRG; PLEKHC3 |
| NCBI Protein Information: | FERM, ARHGEF and pleckstrin domain-containing protein 2; FERM, RhoGEF and pleckstrin domain-containing protein 2 |
| UniProt Protein Name: | FERM, ARHGEF and pleckstrin domain-containing protein 2 |
| UniProt Synonym Protein Names: | FERM domain-including RhoGEF; FIR; FERM, RhoGEF and pleckstrin domain-containing protein 2; Pleckstrin homology domain-containing family C member 3; PH domain-containing family C member 3 |
| UniProt Gene Name: | FARP2 |
| Antibodies | ELISA Kits |
| FARP2 Antibody (PACO00805) | FIR Colorimetric Cell-Based ELISA |
| FARP2 Antibody (PACO09233) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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