FAN1 Antibody (PACO10646)
- SKU:
- PACO10646
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FAN1 Antibody (PACO10646) |
| Antibody SKU: | PACO10646 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Human MTMR15 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | myotubularin related protein 15;MTMR15;DKFZp451H236;DKFZp686K16147;KIAA1018 ; |
| UniProt Protein Function: | FAN1: Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap- specific enzymes to unhook the ICL by cleaving the lagging-strand template. Belongs to the FAN1 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.4.1; Deoxyribonuclease; Ubiquitin conjugating system; DNA repair, damageChromosomal Location of Human Ortholog: 15q13.2-q13.3Cellular Component: cytoplasm; intercellular bridge; nucleoplasm; nucleusMolecular Function: 5'-3' exonuclease activity; 5'-flap endonuclease activity; magnesium ion binding; protein binding; ubiquitin bindingBiological Process: DNA repair; double-strand break repair via homologous recombination; nucleotide-excision repair; nucleotide-excision repair, DNA incisionDisease: Interstitial Nephritis, Karyomegalic |
| UniProt Protein Details: | |
| NCBI Summary: | This gene plays a role in DNA interstrand cross-link repair and encodes a protein with 5' flap endonuclease and 5'-3' exonuclease activity. Mutations in this gene cause karyomegalic interstitial nephritis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q9Y2M0 |
| NCBI GenInfo Identifier: | 160410012 |
| NCBI Gene ID: | 22909 |
| NCBI Accession: | Q9Y2M0.4 |
| UniProt Secondary Accession: | Q9Y2M0,Q86WU8, A8K4M2 |
| UniProt Related Accession: | Q9Y2M0 |
| Molecular Weight: | 59,498 Da |
| NCBI Full Name: | Fanconi-associated nuclease 1 |
| NCBI Synonym Full Names: | FANCD2/FANCI-associated nuclease 1 |
| NCBI Official Symbol: | FAN1 |
| NCBI Official Synonym Symbols: | KMIN; hFAN1; MTMR15; KIAA1018 |
| NCBI Protein Information: | fanconi-associated nuclease 1 |
| UniProt Protein Name: | Fanconi-associated nuclease 1 |
| UniProt Synonym Protein Names: | FANCD2/FANCI-associated nuclease 1 |
| Protein Family: | Fanconi-associated nuclease |
| UniProt Gene Name: | FAN1 |
| UniProt Entry Name: | FAN1_HUMAN |
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